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Historical background on global cardiometabolic risk, epidemiological aspects of obesity and type 2 diabetes, ABCs of cardiovascular disease risk factors, intra-abdominal adiposity, metabolic syndrome and contribution to cardiometabolic risk.
Research and clinical tools to identify individuals with excess intra-abdominal adiposity and quantify their risk of diabetes and cardiovascular disease (global cardiometabolic risk).
Notions and practical tools to better manage the abdominally obese patient with excess intra-abdominal adiposity and related clustering abnormalities.
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for 1 last update 15 Jul 2020 EpidemiologyEpidemiology
for 1 last update 15 Jul 2020
Many cross-sectional and prospective studies have confirmed the link between obesity and type 2 diabetes. Most individuals with type 2 diabetes are overweight or obese. Studies suggest that about 60-90% of all patients with type 2 diabetes are or have been obese (10, 11). One of the first observations on the association between obesity and type 2 diabetes was published by John in 1929 (15). In the 1960s, the seminal population studies of West and Kalbfleisch (16) demonstrated the strong association between overweight and diabetes. They reported that a population’s degree of obesity was the key environmental factor influencing diabetes prevalence reverses diabetes type 2 in children (☑ vitamins) | reverses diabetes type 2 overweighthow to reverses diabetes type 2 for (17)(17). Similarly, a study conducted in the Pima Indian population—a community at high risk of type 2 diabetes—revealed that the probability of developing type 2 diabetes rose with increasing body mass index (BMI) (18). More recently, data from the Third National Health and Nutrition Examination Survey (NHANES III) (19) showed a strong increase in type 2 diabetes among both overweight and obese men and women with increasing weight classes. Recent prospective studies have also tied increasing weight to an increased risk of type 2 diabetes. For instance, the Nurses’ Health Study (20)—a 14 year follow-up study of 11,824 women aged 30-55 years—found the risk of developing type 2 diabetes was 49 times higher among women whose baseline BMI was >35 kg/m2 than among women whose baseline BMI was <22 kg/m2 (Figure). The risk of developing the disease increased fourfold when BMI was between 23.0 and 25.0 kg/m2 and even lean women with a BMI of 22.0 to 22.9 kg/m2 had a significant threefold increase in their risk of type 2 diabetes compared to women with a BMI <22.0 kg/m2. They also found that weight gain of 7.0 to 10.9 kg after the age of 18 was associated with a twofold increase in the risk of type 2 diabetes, the increase in risk being proportionate to the degree of weight gain.
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