Parkinson''div-gpt-ad-1450190541376-0''div-gpt-ad-1450190541376-1''s power plants, the mitochondria, to other parts of the cell, to be used for insulin secretion.
At constant high levels of glucose, however, the levels of the VDAC1 protein increase, causing VDAC1 to attach also to the cell surface. The energy (ATP) then leaks out of the cell and causes cell death due to a lack of energy. This, in turn, leads to impaired blood glucose control that eventually causes organ complications, such as cardiovascular disease, kidney disease, blindness and stroke.
Normalised insulin secretion
When the researchers blocked VDAC1 in beta cells from organ donors with type 2 diabetes, the energy supply was restored and the insulin secretion was normalised.
The experiments were subsequently repeated on mice, which are known to develop genetically conditioned diabetes. As a result, the disease did not develop and the insulin production was maintained for five weeks, at which point the treatment was discontinued and the glucose levels increased.
"", says Albert the 1 last update 15 Jul 2020 Salehi."", says Albert Salehi.
New discoveries about metformin
In addition for 1 last update 15 Jul 2020 to specific VDAC1 antibodies and VDAC1 inhibitors obtained in collaboration with Israeli researchers, the researchers in Lund also used the diabetes drug, metformin, and achieved the same effect.In addition to specific VDAC1 antibodies and VDAC1 inhibitors obtained in collaboration with Israeli researchers, the researchers in Lund also used the diabetes drug, metformin, and achieved the same effect.
"", says Albert Salehi.
Connection to Alzheimer''s disease. The authors of the study point out that there is also a link between VDAC1 and Alzheimer''s opposites: when VDAC1 increases, VDAC2 decreases and vice versa. This discovery was also made by our research team.
Using confocal microscopes, the researchers were able to locate VDAC1 but not VDAC2 to the surface of the beta cells in type 2 diabetics. In healthy cells and the cells from people who were treated with metformin, the protein was rather located inside the cells on the mitochondria. This was confirmed by immunofluorescence staining of the pancreas of non-diabetics and type 2 diabetics.
Enming Zhang et al. Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells, Cell Metabolism
(2018). DOI: 10.1016/j.cmet.2018.09.008
Citation: New discovery restores insulin cell function in type 2 diabetes (2018, October 8) retrieved 11 May 2020 from https://medicalxpress.com/news/2018-10-discovery-insulin-cell-function-diabetes.html
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