reverses diabetes type 2 MODY7: The Krupple-like factor 11 (gene symbol: KLF11) protein is a zinc-finger transcription factor that is involved in activation of the insulin promoter. KLF11 is a ...diabetes type 2 medical journal
the 1 last update 10 Jul 2020
reverses diabetes type 2 charts (🔥 in a sentence) | reverses diabetes type 2 handshow to reverses diabetes type 2 for The development of type II diabetes requires impaired beta-cell function. Chronic hyperglycemia has been shown to induce multiple defects in beta-cells. Hyperglycemia has been proposed to lead to large amounts of reactive oxygen species (ROS) in beta-cells, with subsequent damage to cellular components including PDX-1. Loss of PDX-1, a critical regulator of insulin promoter activity, has also been proposed as an important mechanism leading to beta-cell dysfunction.
Although there is little doubt as to the importance of genetic factors in type II diabetes, genetic analysis is difficult due to complex interaction among multiple susceptibility genes and between genetic and environmental factors. Genetic studies have therefore given very diverse results. Kir6.2 and IRS are two of the candidate genes. It is known that Kir6.2 and IRS play central roles in insulin secretion and insulin signal transmission, respectively.
Source: KEGGProteins on this pathway have targeted assays available via the CPTAC Assay Portal.
|TNF alpha||GeneProduct||ENSG00000232810 (Ensembl)|
No annotated interactions