reverses diabetes type 2

πŸ”₯+ reverses diabetes type 2 27 May 2020 Find an overview about diabetes, the different types, risk factors, and the impact it has ... National Diabetes Statistics Report · Data & Statistics · Diabetes Articles ...

reverses diabetes type 2 The rate of death from diabetes is decreasing in metropolitan America while the rate remains relatively unchanged in rural areas. Researchers ...

childhood type 2 diabetes rates

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1-4Insulin signaling pathwayROSDNAPancreatic beta cellCa 2+ dependentGlucose ( hyperglycemia)transient hyperglycemia hyperinsulinismPrevention of membrane depolarization+py (tyrosine phosphorylation)ObesityK+Adipoctokine signaling pathway+ps (serine phosphorylation)Insulin ResistanceImpaired Insulin Secretionglycation, hexosamine pathway,respiratory chainFFAType II diabetes mellitusMaturity onsetdiabetes of the youngAdipotocyte, heptocyte, skeletal muscle cell Adipocytokine Signaling PathwayobesityINSIKKGlucoseJNKmTORVDCCMafASOCSJNKPyruvateIRSADIPOINSTNF alphaERKATPPDX-1P13KCa2+GLUT2GLUT4GKApoptosis PRKCDPYKKir6.2IRSPRKCZINSRSURF1

the 1 last update 27 May 2020

Description

Insulin resistance is strongly associated with type II diabetes. "" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression, modification of the cellular localization, and degradation represent the molecular mechanisms stimulated by them. Various kinases (ERK, JNK, IKKbeta, PKCzeta, PKCtheta and mTOR) are involved in this process.

reverses diabetes type 2 other names (πŸ”΄ info) | reverses diabetes type 2 usually appears after age 40how to reverses diabetes type 2 for The development of type II diabetes requires impaired beta-cell function. Chronic hyperglycemia has been shown to induce multiple defects in beta-cells. Hyperglycemia has been proposed to lead to large amounts of reactive oxygen species (ROS) in beta-cells, with subsequent damage to cellular components including PDX-1. Loss of PDX-1, a critical regulator of insulin promoter activity, has also been proposed as an important mechanism leading to beta-cell dysfunction.

Although there is little doubt as to the importance of genetic factors in type II diabetes, genetic analysis is difficult due to complex interaction among multiple susceptibility genes and between genetic and environmental factors. Genetic studies have therefore given very diverse results. Kir6.2 and IRS are two of the candidate genes. It is known that Kir6.2 and IRS play central roles in insulin secretion and insulin signal transmission, respectively. 

Source: KEGG

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Bibliography

  1. Chandra J, Zhivotovsky B, Zaitsev S, Juntti-Berggren L, Berggren PO, Orrenius S; ''Role of apoptosis in pancreatic beta-cell death in diabetes.''; Diabetes, 2001 PubMed Europe PMC
  2. Kaneto H, Matsuoka TA, Nakatani Y, Kawamori D, Miyatsuka T, Matsuhisa M, Yamasaki Y; ''Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes.''; J Mol Med (Berl), 2005 PubMed Europe PMC
  3. Henquin JC; ''Triggering and amplifying pathways of regulation of insulin secretion by glucose.''; Diabetes, 2000 PubMed Europe PMC
  4. Gual P, Le Marchand-Brustel Y, Tanti JF; ''Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.''; Biochimie, 2005 PubMed Europe PMC

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108356view19:37, 11 December 2019KhanspersOntology Term : '' added !
106156view12:05, 16 August 2019MaintBotHMDB identifier normalization
105849view23:15, 15 August 2019KhanspersModified description
94959view10:10, 20 October 2017DeSlAdded lit. references
94958view09:44, 20 October 2017DeSlConnected all lines that I could
81779view19:00, 26 August 2015KhanspersModified description
81778view18:58, 26 August 2015KhanspersModified description
72094view21:35, 24 October 2013Mkutmonupdated datasource for ""
67730view11:55, 26 June 2013DdiglesOntology Term : '' added !
63481view18:29, 10 May 2013AlexanderPicoFixed Xref for PYK
63274view07:16, 9 May 2013EveloPeriodical save, work in progress
59217view20:13, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
45036view18:50, 6 October 2011KhanspersOntology Term : '' added !
45034view18:49, 6 October 2011KhanspersOntology Term : '' added !
45032view18:47, 6 October 2011KhanspersOntology Term : '' removed !
45031view18:47, 6 October 2011KhanspersOntology Term : '' added !
45030view18:47, 6 October 2011KhanspersOntology Term : '' added !
41223view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
38693view18:35, 23 September 2010KhanspersChanged layout, connected nodes, added metabolites, added pathway links, fixed arrows
38692view18:26, 23 September 2010KhanspersPeriodical save, work in progress
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37812view15:04, 5 July 2010Ankudiabetes type II
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External the 1 last update 27 May 2020 references External references

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NameTypeDatabase referenceComment
PRKCDGeneProductENSG00000163932 (Ensembl)
ADIPOGeneProductENSG00000181092 (Ensembl)
ATPMetaboliteHMDB0000538 (HMDB)
ApoptosisPathwayWP254 (WikiPathways)
Ca2+MetaboliteHMDB0000464 (HMDB)
ERKGeneProductENSG00000100030 (Ensembl)
GKGeneProductENSG00000198814 (Ensembl)
GLUT2GeneProductENSG00000163581 (Ensembl)
GLUT4GeneProductENSG00000181856 (Ensembl)
GlucoseMetaboliteHMDB0000122 (HMDB)
IKKGeneProductENSG00000104365 (Ensembl)
INSGeneProductENSG00000129965 (Ensembl)
INSRGeneProductENSG00000171105 (Ensembl)
IRSGeneProductENSG00000169047 (Ensembl)
JNKGeneProductENSG00000107643 (Ensembl)
Kir6.2GeneProductENSG00000187486 (Ensembl)
MafAGeneProductENSG00000182759 (Ensembl)
P13KGeneProductENSG00000141506 (Ensembl)
PDX-1GeneProductENSG00000139515 (Ensembl)
PRKCZGeneProductENSG00000067606 (Ensembl)
PYKGeneProductENSG00000044446 (Ensembl)
PyruvateMetaboliteHMDB0000243 (HMDB)
SOCSGeneProductENSG00000180008 (Ensembl)
SURF1GeneProductENSG00000148290 (Ensembl)
TNF alphaGeneProductENSG00000232810 (Ensembl)
VDCCGeneProductENSG00000141837 (Ensembl)
mTORGeneProductENSG00000198793 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from ""https://www.wikipathways.org/index.php/Pathway:WP1584""
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